{"id":7684,"date":"2025-08-28T14:15:30","date_gmt":"2025-08-28T12:15:30","guid":{"rendered":"https:\/\/strokeneurorehab.com\/?p=7684"},"modified":"2025-08-28T14:15:32","modified_gmt":"2025-08-28T12:15:32","slug":"51-teny-belflora-agy-osszefuggesei","status":"publish","type":"post","link":"https:\/\/strokeneurorehab.com\/en\/51-teny-belflora-agy-osszefuggesei\/","title":{"rendered":"5\u202f+\u202f1 t\u00e9ny: A b\u00e9lfl\u00f3ra \u00e9s az agyi \u00e9rh\u00e1l\u00f3zat \u00f6sszef\u00fcgg\u00e9sei stroke eset\u00e9n"},"content":{"rendered":"\n

A b\u00e9l\u2013agy tengely \u00e9s a stroke kapcsolata a tudom\u00e1ny egyik legizgalmasabb, gyorsan fejl\u0151d\u0151 ter\u00fclete. Az al\u00e1bbiakban 5\u202f+\u202f1 \u00e9rdekes t\u00e9nyt mutatunk be r\u00f6viden, tudom\u00e1nyos forr\u00e1sokkal al\u00e1t\u00e1masztva.<\/p>\n\n\n\n

1. A microbiota\u2013gut\u2013brain axis: k\u00e9tir\u00e1ny\u00fa kommunik\u00e1ci\u00f3<\/h2>\n\n\n\n

A b\u00e9l\u2013agy tengely (gut\u2011brain axis) mag\u00e1ban foglalja az idegrendszer, a hormon\u00e1lis \u00e9s immunrendszeri \u00fatvonalak, valamint a k\u00f6rnyez\u0151 vegyi anyagok \u00f6sszj\u00e1t\u00e9k\u00e1t. A b\u00e9lbakt\u00e9riumok termelnek neurotranszmittereket, citokineket, r\u00f6vid l\u00e1nc\u00fa zs\u00edrsavakat (SCFA), amelyek befoly\u00e1solhatj\u00e1k az agy m\u0171k\u00f6d\u00e9s\u00e9t \u00e9s a v\u00e9r-agy g\u00e1t integrit\u00e1s\u00e1t. [1]<\/p>\n\n\n\n

Mit is jelent ez pontosan?<\/strong><\/p>\n\n\n\n

\u2192 A b\u00e9lbakt\u00e9riumok \u00e1ltal termelt vegy\u00fcletek (pl. SCFA) jav\u00edthatj\u00e1k az \u00e9rfalak rugalmass\u00e1g\u00e1t \u00e9s cs\u00f6kkenthetik a gyullad\u00e1st, m\u00edg a k\u00e1ros b\u00e9lfl\u00f3ra gyullad\u00e1sos reakci\u00f3kat ind\u00edthat, ami fokozza az \u00e9relmeszesed\u00e9s \u00e9s a stroke kock\u00e1zat\u00e1t.<\/em><\/p>\n\n\n\n

2. Stroke ut\u00e1ni b\u00e9lfl\u00f3ra-diszbi\u00f3zis<\/h2>\n\n\n\n

Isch\u00e9mi\u00e1s stroke ut\u00e1n mind \u00e1llatk\u00eds\u00e9rletekben, mind emberekn\u00e9l kimutatt\u00e1k a b\u00e9lbakt\u00e9riumok \u00f6sszet\u00e9tel\u00e9nek jelent\u0151s v\u00e1ltoz\u00e1s\u00e1t: cs\u00f6kken a diverzit\u00e1s, p\u00e9ld\u00e1ul kevesebb SCFA\u2011termel\u0151 bakt\u00e9rium van jelen, m\u00edg Enterobacteriaceae-t\u00edpus\u00fa bakt\u00e9riumok t\u00fals\u00falyba ker\u00fclnek. [3, 7]<\/p>\n\n\n\n

\u2192 A stroke okozta idegrendszeri k\u00e1rosod\u00e1s megv\u00e1ltoztatja a b\u00e9lm\u0171k\u00f6d\u00e9st \u00e9s a bakt\u00e9rium-\u00f6sszet\u00e9telt, ami tov\u00e1bbi gyullad\u00e1st v\u00e1lthat ki, lass\u00edtva a gy\u00f3gyul\u00e1st \u00e9s n\u00f6velve az ism\u00e9telt stroke es\u00e9ly\u00e9t.<\/em><\/p>\n\n\n\n

3. Fiziol\u00f3giai \u00fatvonalak: immunrendszer, neurotranszmitterek \u00e9s \u00e9rrendszer<\/h2>\n\n\n\n

A stroke aktiv\u00e1lja a b\u00e9lb\u0151l kiindul\u00f3 gyullad\u00e1sos folyamatokat, \u00e9s a b\u00e9l barrier \u00e1tereszt\u0151bb\u00e9 v\u00e1lik (\u201cleaky gut\u201d), \u00edgy immunsejtek \u00e9s gyullad\u00e1sos molekul\u00e1k ker\u00fclhetnek az agyba, s\u00falyosb\u00edtva az agyi k\u00e1rosod\u00e1st. [4]<\/p>\n\n\n\n

\u2192 A s\u00e9r\u00fclt b\u00e9lg\u00e1t miatt gyullad\u00e1sos anyagok juthatnak a v\u00e9r\u00e1ramba \u00e9s az agyba, s\u00falyosb\u00edtva az agyi \u00e9rk\u00e1rosod\u00e1st, rontva a fel\u00e9p\u00fcl\u00e9st \u00e9s n\u00f6velve a m\u00e1sodlagos agyi k\u00e1rosod\u00e1sok kock\u00e1zat\u00e1t.<\/em><\/p>\n\n\n\n

4. Typus-specifikus mikrobiom-profil k\u00fcl\u00f6nbs\u00e9gek<\/h2>\n\n\n\n

2024-ben v\u00e9gzett vizsg\u00e1latok szerint az isch\u00e9mi\u00e1s \u00e9s hemorrhagi\u00e1s stroke betegek b\u00e9lfl\u00f3r\u00e1ja mark\u00e1nsan elt\u00e9r: isch\u00e9mi\u00e1s stroke eset\u00e9n p\u00e9ld\u00e1ul t\u00f6bb Proteobacteria \u00e9s Butyricimonas, hemisphagi\u00e1s eset\u00e9n viszont t\u00f6bb Fusobacteria \u00e9s m\u00e1s nemzetts\u00e9gek jelennek meg. [6]<\/p>\n\n\n\n

\u2192 A stroke t\u00edpusa (isch\u00e9mi\u00e1s, v\u00e9rz\u00e9ses) m\u00e1s-m\u00e1s bakt\u00e9riumar\u00e1nyokat hoz l\u00e9tre, ami elt\u00e9r\u0151 gyullad\u00e1sos \u00e9s anyagcsere-folyamatokat ind\u00edthat, \u00edgy m\u00e1sk\u00e9pp befoly\u00e1solhatja a kimenetelt \u00e9s a rehabilit\u00e1ci\u00f3s strat\u00e9gi\u00e1t.<\/em><\/p>\n\n\n\n

5. A b\u00e9lfl\u00f3ra befoly\u00e1solhatja a stroke kimenetel\u00e9t<\/h2>\n\n\n\n

A stroke s\u00falyoss\u00e1g\u00e1val korrel\u00e1l\u00f3 b\u00e9lfl\u00f3ra\u2011v\u00e1ltoz\u00e1sok mellett egyes kutat\u00e1sok arra is r\u00e1mutatnak, hogy a probiotikumok, prebiotikumok, valamint a b\u00e9lfl\u00f3ra-transzplant\u00e1ci\u00f3 (FMT) jav\u00edthatj\u00e1k a stroke ut\u00e1ni fel\u00e9p\u00fcl\u00e9st, cs\u00f6kkenthetik a gyullad\u00e1st \u00e9s t\u00e1mogathatj\u00e1k az idegi regener\u00e1ci\u00f3t. [7, 8, 9]<\/p>\n\n\n\n

\u2192 A j\u00f3t\u00e9kony b\u00e9lbakt\u00e9riumok helyre\u00e1ll\u00edt\u00e1sa (probiotikum, prebiotikum, FMT) cs\u00f6kkentheti a gyullad\u00e1st, t\u00e1mogatja az idegsejtek regener\u00e1ci\u00f3j\u00e1t, \u00e9s gyors\u00edthatja a funkci\u00f3k visszanyer\u00e9s\u00e9t.<\/em><\/p>\n\n\n\n

+1. El\u0151rejelz\u00e9s \u00e9s prevenci\u00f3: \u00faj izgalmas ir\u00e1ny<\/h2>\n\n\n\n

Egy 2025\u2011\u00f6s jap\u00e1n kutat\u00e1s szerint a Streptococcus anginosus bakt\u00e9rium a sz\u00e1jban \u00e9s a b\u00e9lben nagyobb mennyis\u00e9gben fordult el\u0151 stroke-on \u00e1tesett betegekben. Ennek jelenl\u00e9te magasabb hal\u00e1loz\u00e1si \u00e9s \u00faj kardiovaszkul\u00e1ris esem\u00e9ny (pl. \u00fajabb stroke) kock\u00e1zattal j\u00e1rt a k\u00f6vet\u00e9s sor\u00e1n. Ez potenci\u00e1lisan \u00faj diagnosztikai lehet\u0151s\u00e9get jelenthet a stroke kock\u00e1zat felm\u00e9r\u00e9s\u00e9re, illetve c\u00e9lzott bakt\u00e9riumellenes strat\u00e9gi\u00e1kat alapozhat meg. [9, 10]<\/p>\n\n\n\n

\u2192 Bizonyos bakt\u00e9riumfajok (pl. Streptococcus anginosus) jelenl\u00e9te el\u0151re jelezheti a fokozott stroke-rizik\u00f3t, \u00edgy korai sz\u0171r\u00e9s \u00e9s c\u00e9lzott beavatkoz\u00e1s (pl. sz\u00e1jhigi\u00e9nia, b\u00e9lfl\u00f3ra-rendez\u00e9s) cs\u00f6kkentheti a bek\u00f6vetkez\u00e9s es\u00e9ly\u00e9t.<\/em><\/p>\n\n\n\n

Forr\u00e1sok<\/h2>\n\n\n\n
    \n
  1. 1. Wikipedia \u2013 Gut\u2013brain axis:<\/li>\n\n\n\n
  2. \u00a0https:\/\/en.wikipedia.org\/wiki\/Gut%E2%80%93brain_axis<\/a><\/li>\n\n\n\n
  3. 2. Neurological Research and Practice \u2013 Gut microbiota changes after stroke: https:\/\/neurolrespract.biomedcentral.com\/articles\/10.1186\/s42466-022-00222-8<\/a><\/li>\n\n\n\n
  4. 3. PubMed \u2013 Gut microbiota dysbiosis in stroke patients: https:\/\/pubmed.ncbi.nlm.nih.gov\/35135325\/<\/a><\/li>\n\n\n\n
  5. 4. Frontiers in Neuroscience \u2013 Gut barrier dysfunction in stroke: https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1081347\/full<\/a><\/li>\n\n\n\n
  6. 5. European Journal of Medical Research \u2013 Microbiome and neuroinflammation: https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-022-00691-2<\/a><\/li>\n\n\n\n
  7. 6. Scientific Reports (Nature) \u2013 Stroke type-specific gut microbiota patterns: https:\/\/www.nature.com\/articles\/s41598-024-62606-x<\/a><\/li>\n\n\n\n
  8. 7. MDPI Biomolecules \u2013 Microbiota-targeted interventions in stroke: https:\/\/www.mdpi.com\/2218-273X\/15\/7\/920<\/a><\/li>\n\n\n\n
  9. 8. PMC \u2013 Gut microbiota in post-stroke recovery: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10315190\/<\/a><\/li>\n\n\n\n
  10. 9. The Sun \u2013 Bacteria linked to increased stroke risk: https:\/\/www.thesun.co.uk\/health\/33092909\/bacteria-mouth-gut-raise-risk-stroke-risk-factors\/<\/a><\/li>\n\n\n\n
  11. 10. EatingWell \u2013 Study on Streptococcus anginosus and stroke: https:\/\/www.eatingwell.com\/stroke-risk-bacteria-study-8785920<\/a><\/li>\n<\/ol>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    A b\u00e9l\u2013agy tengely \u00e9s a stroke kapcsolata a tudom\u00e1ny egyik legizgalmasabb, gyorsan fejl\u0151d\u0151 ter\u00fclete. Az al\u00e1bbiakban 5\u202f+\u202f1 \u00e9rdekes t\u00e9nyt mutatunk […]<\/p>\n","protected":false},"author":1,"featured_media":7685,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\n5\u202f+\u202f1 t\u00e9ny: A b\u00e9lfl\u00f3ra \u00e9s az agyi \u00e9rh\u00e1l\u00f3zat \u00f6sszef\u00fcgg\u00e9sei stroke eset\u00e9n<\/title>\n<meta name=\"description\" content=\"A b\u00e9l\u2013agy tengely \u00e9s a stroke kapcsolata a tudom\u00e1ny egyik legizgalmasabb, gyorsan fejl\u0151d\u0151 ter\u00fclete. 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